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Technological Advancements in Chromatography: Transforming the Chromatography Consumables Market

   February 17, 2021

Chromatography is a method of separating components of a mixture. The main idea of the process is that distinct compounds have different solubility levels, causing them to travel through the stationary phase at different speeds, resulting in their separation as more highly soluble compounds separate faster than those with lower solubility. This method is adopted by a wide range of industries, namely, pharma, research, biotechnology, and F&B. Continuous advancements in chromatographic techniques have established chromatography as a standard laboratory technique across sectors, allowing it to remain relevant and useful in meeting analytical demands across various scientific scenarios. Liquid chromatography is among the majorly preferred types of chromatography technologies and is replacing gas chromatography in some applications.

Technological advancements in liquid chromatography are boosting the demand for chromatography consumables. For instance, in the food industry, liquid chromatography with ultraviolet detection (LC-UV), liquid chromatography with mass spectroscopy (LC-MS), and liquid chromatography with high-resolution mass spectroscopy (LC-HRMS) are studied to address issues regarding food safety and authenticity. Thus, the adoption of liquid chromatography consumables is further expected to grow.

Reversed-phase liquid chromatography (RPLC) has been used as the gold standard for pharmaceutical analysis. However, in recent years, the cost of drug development has continued to increase the complexity of drug discovery processes compelling the pharmaceutical industry to demand better performance from the RPLC method, both in terms of throughput and resolution. Thus, the ultra-high performance liquid chromatography (UHPLC) technique was developed to meet this increasing demand. This updated technique allows for higher efficiency and increased throughput than conventional chromatography methods.

Since the development of UHPLC, chromatography methods have seen further advancements due to pressure from the pharmaceutical industry. In recent years, there has been an increase in research related to protein biopharmaceuticals, such as monoclonal antibodies. These novel classes of biomolecules have specific analytical needs, which have forced the evolution of chromatography methods to meet these needs. Recently, several innovative chromatographic columns have emerged in the market, primarily for pharmaceutical applications, such as the analysis of protein biopharmaceuticals and chiral drugs and detecting genotoxic impurities, driving the adoption of chromatography in the pharmaceutical industry. Some of the innovative HPLC column advancements impacting pharmaceutical analysis are sub-2 μm particles, core-shell particles, hybrid particles, novel bonding chemistries, Hydrophilic Interaction Chromatography (HILIC), and immobilized polysaccharide chiral stationary phases.

Apart from pharma research, researchers are also working in metabolomics as it offers a way to measure cell response to internal or external stimuli, allowing them to grow their knowledge of human biology at the cellular level. For many years, mass spectrometry has been the most widely used analytics platform for metabolomics. However, recently, the method has been coupled with LC or GC to enhance sensitivity and resolution while analyzing metabolites in a sample. Advancements in column chemistries have further created an enhanced LC-MS method, allowing wider metabolome coverage. Additionally, GC-MS has recently benefitted from developments in column stationary phases (SPs), which has increased the number of metabolites that are detectable by GC-MS.

In forensics, gas chromatography is used to determine if a deceased person has taken any alcohol or drugs prior to death, as well as determining if they had been poisoned. This is crucial information when trying to determine how a person has died. Chromatography techniques are used to identify and measure criminal samples such as drugs, biological fluids, tissues, and synthetic samples. There have been advancements in methodologies, improving forensic analysis methods' accuracy and efficiency. For instance, the high-resolution liquid chromatography-mass spectrometry (LC-MS) technique has been developed to enhance the power of traditional high-resolution mass spectrometry (HRMS), further allowing researchers to analyze complex matrices and reduce interference during analysis.

Thus, such technological advancements in chromatography are expected to drive the global chromatography consumables market at a CAGR of 6.0% to reach $3.6 billion by 2027, according to the Meticulous Research.

Meticulous Research’s Repository for Chromatography Include:

Chromatography Data Systems Market (CDS Market) Size by Product (Standalone software, Integrated software), by Delivery Mode (Web Based, On-Premise and Cloud Based), End User (Academic & Research Institutes, Pharmaceutical & Biopharmaceutical Industry, Biotechnology Industry, Food & Beverage Industry, Environmental Testing, Others) - Global Forecasts to 2022

Chromatography Market Size, by Systems (Liquid Chromatography, Gas Chromatography, Supercritical Fluid Chromatography, and Thin-Layer Chromatography), by Accessories (Detectors, Auto-Samplers, Pumps and Flow Meters, Fraction Collectors, and Others), by Consumables (Columns, Vials, Tubings, and other Consumables), by End User - Global Forecast to 2022

Chromatography Syringes Market by Type (Gas Chromatography syringes, Liquid Chromatography syringes and Thin-layer Chromatography syringes), by End-user (Pharmaceutical and Biotechnology Industries, Academics and Research Institutes, Food and Beverage Industries, Hospitals/Clinics, Environmental Agencies, and Others), and by Geography - Global Forecast to 2022

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