The growth in the biopharmaceutical industry is encouraging innovations in the field and further leading to the demand for cell culture products for drug discovery and safety testing. Drug target validation, the most crucial step in drug discovery, was conventionally carried out with the help of 2D cell cultures, used to model diseases under carefully controlled conditions. However, these monolayers of cells lack physiological relevance as they poorly mimic the complexity of human tissues and the disease they are modeling. Due to these reasons, 3D cell models are gaining popularity as they exhibit a higher degree of morphological and functional representative of in vivo environments. Hence, using more physiologically relevant models enables more appropriate drug candidate analysis earlier in the development process.
3D cell cultures allow researchers to make better-informed predictions as they exhibit many characteristics which remain unseen in the monolayers of traditional 2D model systems. 3D cultures also simulate the extracellular matrix, maintain cell viability, and retain tissue microenvironment, enabling correct cellular differentiation, communication, and function.
The broad spectrum of 3D cell culture models ranges from scaffold-free spheroids of cancer cell lines to complex microfluidic devices containing several organoids representing a human-on-a-chip. The liver and heart-specific 3D cell culture platforms have been an important focus as cardiotoxicity and hepatotoxicity are the main causes of drug attrition. Also, the 3D cell culture technique enables the personalized treatment of diseases such as cancer by allowing researchers to understand the contributions of different cell types in those particular diseases.
Personalized medicine, also known as precision medicine, is an emerging approach to the treatment and prevention of the disease which considers individual variability in genes, environment, and lifestyle. This approach allows doctors and researchers to predict more accurately which treatment and prevention strategies for a particular disease will work in which groups of people. From targeting late-stage cancers to curing rare genetic diseases, precision medicine is poised to impact millions of people within the next decade. Hence, internationally, every region is coming together to make personalized medicine more effective and possible for every individual. Hence, there will be an increase in the adoption of personalized medicine in the coming years.
At a basic level, personalized medicines are studied using cell cultures, primarily 3D cell cultures, which help improve drug response prediction and therapeutic outcomes. Thus, the rising adoption of 3D cell culture is expected to drive the global cell culture media market at a CAGR of 13.2% to reach $14.64 billion by 2029, according to Meticulous Research®.
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