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Spatial Genomics & Transcriptomics: The Emerging Molecular Profiling Method

   January 9, 2024

Spatial genomics and transcriptomics are still in the early stages of development, and scientists are actively exploring their applications across various fields such as oncology, neurology, developmental biology, and more. As the need intensifies to map genomes and transcriptomes for a positional understanding of differences between normal and diseased tissues, the demand for spatial technologies is on the rise. Increased research activities have resulted in a substantial uptick in funding for spatial genomics research, facilitating the development of advanced detection technologies and data visualization or imaging tools. These advancements enable the analysis of vast genomic data sets. Spatial genomics research plays a crucial role in uncovering new drugs, developing personalized medicines, and enhancing researchers' comprehension of disease mechanisms.

Spatial Genomics & Transcriptomics in Neurology Research

Spatial genomics holds significant promise for offering insights into the molecular and cellular mechanisms that underlie diverse neurological disorders. In neurology, spatial genomics applications encompass the spatial profiling of brain tissues, the identification of cell types, the characterization of neuroinflammation, the exploration of neural circuits, and drug discovery and target identification. Through the comparison of spatial gene expression profiles between healthy and diseased brain tissues, researchers can pinpoint specific molecular signatures associated with neurological disorders, paving the way for the discovery of novel biomarkers.

The increasing prevalence of neurological disorders is driving research in the field of spatial genomics for neurology. For example, according to the Alzheimer’s Association (U.S.), as of 2023, an estimated 6.7 million Americans aged 65 and older were living with Alzheimer’s disease, a prevalent form of dementia. Moreover, projections indicate a 68% increase in the prevalence of dementia in middle- and low-income countries by 2050. Spatial genomics offers the ability to study the spatial distribution of inflammatory markers and immune cell populations within the brain, providing valuable insights into the inflammatory processes associated with conditions such as Alzheimer’s disease or multiple sclerosis.

The key market players, including NanoString Technologies, Inc. (U.S.), Vizgen Inc. (U.S.), and Resolve Biosciences GmbH (Germany), are providing the spatial genomics & transcriptomics panels & assays for neurology research.

Microfluidic Spatial Transcriptomics is Expected to Gain Traction in the Market

In recent years, the integration of microfluidic technology with spatial genomics and transcriptomics innovations has become a notable trend. The merging of Fluorescent In Situ Hybridization (FISH) with microfluidic technology has led to the automated sequential detection of numerous targets. This method is employed to construct an image utilizing up to 1000 probes, facilitating the visualization of spatial patterns of gene expression.

The incorporation of microfluidic technology with techniques like seqFISH (sequential Fluorescence In Situ Hybridization) or MERFISH (Multiplexed Error-Robust Fluorescence In Situ Hybridization) is recognized as one of the most effective and reliable approaches for observing multiple genes and their spatial configuration. Furthermore, microfluidic technology enables experiments with a reduced amount of buffer and dye solutions while remaining compatible with biological applications and microscope observations.

The utilization of microfluidic platforms and lab-on-chip technologies brings several enhancements to seqFISH and MERFISH methodologies. These improvements primarily focus on reducing costs, which can be substantial for these methods, introducing automation in the process, enabling multiplexed detection, and shortening the time required for experiments.

Insights from Spatial Genomics & Transcriptomics Market Analysis

Recent insights from Meticulous Research® provide valuable perspectives on the future trajectory of the Spatial Genomics Market. Projections suggest a potential worth of $3.23 billion by 2031, driven by a remarkable Compound Annual Growth Rate (CAGR) of 27.8% from 2024 to 2031. The recent focus on research & development of spatial genomics is driving innovation in the field. Moreover, significant trends are emerging due to the ongoing evolution, such as automation of assays, multiplexed detection, combination of microfluidic technology with detection technology, and increasing advancements in data visualization tools.

As the global landscape takes shape, the North American region is expected to hold a substantial market share in 2024. Notably, influential industry players, including NanoString Technologies, Inc. (U.S.), 10X Genomics, Inc. (U.S.), Illumina, Inc. (U.S.), Akoya Biosciences, Inc. (U.S.) and others have established a broad presence across various regions, leading to the widespread adoption of their products. In essence, this comprehensive overview from Meticulous Research serves as a gateway into the spatial genomics & transcriptomics market.


The spatial genomics market is currently in its early stages of development and is poised to witness significant growth in the coming years. Key factors driving this growth include the expanding applications of spatial genomics in drug discovery and development, the increasing utilization of spatial genomics in cancer research, advancements in Next-generation Sequencing (NGS), the growing use of spatial genomics in biomarker detection, and the escalating prevalence of cancer.

Moreover, the rising adoption of personalized medicines and gene therapies, coupled with increased investments in spatial genomics, are anticipated to create favorable growth opportunities for the market players in this space.

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