NGS Library Preparation Market by Product (Kits, Reagents, Instruments), Sequencing Type (Genome, Exome, Targeted), Application (Diagnostics, Discovery), End User (Hospitals, Diagnostic Laboratories, Pharmaceutical, Academic) – Global Forecast to 2030

The NGS Library Preparation Market is expected to reach $6.47 billion by 2030 at a CAGR of 16% from 2023 to 2030. The typical NGS workflow involves several steps, including sample pre-processing, library preparation, sequencing, and bioinformatics. Library preparation is a crucial step in NGS workflow and involves preparing DNA or RNA samples to be compatible with a sequencer. It includes processes such as nucleic acid fragmentation, adapter ligation, and library quantitation. Numerous vendors offer a variety of NGS library preparation solutions for NGS analysis.

The growth of this market is driven by the declining costs of sequencing, the increasing prevalence of cancer and genetic disorders, the growing utilization of NGS in disease diagnostics and precision medicine, and rising R&D investments and healthcare expenditures. In addition, the increasing applications of next-generation sequencing technology and collaborations between vendors to develop automated library preparation protocols are expected to provide significant market growth opportunities.

However, the availability of alternative technologies and the low chances of identifying positive actionable mutations for precision medicine is expected to hinder the growth of this market to a certain extent. In addition, factors such as the regulatory and standardization concerns in diagnostic testing and the limited expertise and sequencing capabilities of small & mid-sized laboratories are the major challenges for the growth of this market.

The Impact of COVID-19 on the NGS Library Preparation Market

Next-generation sequencing (NGS) is a massively parallel sequencing technology that offers ultra-high throughput, scalability, and speed. This technology is ideal for monitoring the COVID-19 virus and identifying new mutations. The SARS-CoV-2 virus mutated over time, resulting in genetic variation in the population of circulating viral strains. The NGS technology has been successful in identifying the emerging new strains of the virus and helped healthcare institutions take appropriate actions.

The outbreak of the COVID-19 pandemic positively impacted the NGS library preparation market by increasing the adoption of NGS for various applications, including epidemiology, metagenomic analysis, and diagnostics. Furthermore, various companies started developing and launching new NGS-based diagnostic tests to detect the virus. For instance, in April 2021, QIAGEN N.V. (Germany) launched its QIAseq DIRECT SARS-CoV-2 Kit, a viral genome enrichment and library preparation solution for sequencing the SARS-CoV-2 genome. Similarly, in March 2020, Fulgent Genetics, Inc. (U.S.) launched a COVID-19 diagnostic test based on NGS technology.

In the coming years, NGS is expected to play an important role in epidemiological research to distinguish between COVID-19, influenza, and other viruses. These factors are expected to drive the demand for NGS technology, subsequently boosting the growth of the NGS library preparation market.

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Key Findings of the NGS Library Preparation Market Study:

Reagents & Consumables Segment to Dominate Market

Based on product, in 2023, the reagents & consumables segment is expected to account for the largest share of the NGS library preparation market. The large market share of this segment is attributed to factors such as the increasing launches of library preparation kits, the high demand for NGS in clinical diagnostics and drug discovery, and the recurring purchase of reagents and kits.

Research & Other Applications Segment to Dominate Market

Based on application, in 2023, the research & other applications segment is expected to account for the largest share of the NGS library preparation market. The large market share of this segment is attributed to factors such as increasing utilization of NGS for identifying novel drug targets and developing therapeutic techniques that target specific genes, growing investments in drug research and development activities, and increasing research programs for personalized medicines.

Targeted Sequencing Segment to Dominate Market

Based on sequencing type, in 2023, the tareted sequencing segment is expected to account for the largest share of the NGS library preparation market. The large market share of this segment is attributed to factors such as the high adoption of targeted genome sequencing for understanding specific mutations, especially in oncology and research, and its cost-effectiveness.

Pharmaceutical & Biotechnology Companies Segment to Dominate Market

Based on end user, in 2023, the pharmaceutical & biotechnology companies segment is expected to account for the largest share of the NGS library preparation market. The large market share of this segment is attributed to factors such as the increasing applications of NGS in medicine, the growing demand for new drug discoveries and development, increasing number of large-scale genome projects and drug development programs.

Asia-Pacific: The Fastest-growing Regional Market

Asia-Pacific is slated to record the fastest growth rate in the NGS library preparation market during the forecast period. The high market growth in Asia-Pacific is driven by the healthcare infrastructure advancements in the region, the increasing government focus on sequencing projects, the increasing prevalence of various chronic & infectious diseases, a large number of patients with gene-associated disorders, and the rising research activities for the development of personalized medicines.

Key Players

The report includes a competitive landscape based on an extensive assessment of the market based on application, sequencing type, end user, and geography. The report also provides insights into the geographic presence of major market players and their key growth strategies between 2019 and 2022.

The key players profiled in the NGS library preparation market are Illumina, Inc. (U.S.), Thermo Fisher Scientific Inc. (U.S.), QIAGEN N.V. (Germany), Agilent Technologies, Inc. (U.S.), Danaher Corporation (U.S.), Pacific Biosciences of California, Inc. (U.S.), PerkinElmer Inc. (U.S.), F. Hoffmann-La Roche AG (Switzerland), New England Biolabs, Inc. (U.S.), Tecan Group Ltd. (Switzerland), Merck KGaA (Germany), Diagenode S.A. (Belgium) (Subsidiary of Hologic, Inc. (U.S.)), and Beijing Genomics Institute (BGI) (China).

Scope of the Report:

NGS Library Preparation Market, by Product

• Reagents & Consumables
  • DNA Library Preparation
  • RNA Library Preparation
• Instruments & Workstations

NGS Library Preparation Market, by Application

• Research and Other Applications
  • Drug Discovery
  • Agriculture & Animal Research
  • Other Applications
    (Note: Other applications include basic research (genomics, molecular biology, and other life sciences), and forensics & food microbiology.)
• Clinical Application
  • Reproductive Health
  • Oncology
  • Infectious Disease
  • Other Clinical Applications
    (Note: Other clinical applications include applications in detection aberrations in neurological disorders, rare diseases, metabolic and immune disorders, and food-borne illnesses.)

NGS Library Preparation Market, by Sequencing Type

• Targeted Genome Sequencing
• Whole Genome Sequencing
• Whole Exome Sequencing
• Other Sequencing Types
  (Note: Other Sequencing types include degradome sequencing, chromatin immunoprecipitation (ChIP) sequencing, and methylation sequencing)

NGS Library Preparation Market, by End User

• Pharmaceutical & Biotechnology Companies
• Hospitals & Diagnostic Laboratories
• Academic Institutes & Research Centres
• Others End Users
  (Note: Other end users include forensic laboratories & security agencies, the food industry, and the agriculture industry)

NGS Library Preparation Market, by Geography

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • France
  • U.K.
  • Italy
  • Spain
  • Rest of Europe (RoE)
• Asia-Pacific
  • China
  • Japan
  • India
  • Rest of Asia-Pacific (RoAPAC)
• Latin America
• Middle East & Africa

Key questions answered in the report: